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Stop Wastage: Design chemical syntheses to prevent waste, leaving no waste. |
| Safer chemicals and products: Design chemical products that are fully effective, yet have minimal or no toxicity. |
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| Less hazardous chemical syntheses: Design syntheses to use and generate substances with little or no toxicity to humans and the environment. |
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| Renewable Raw Material: Use renewable raw materials and feedstock. They are often made from agricultural products or are the waste of other processes; depleting raw material is made from fossil fuels or is mined. |
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| Catalysts, not stoichiometric reagents: One can minimize waste by using catalytic reactions. Catalysts can be used in small amounts and can carry out a single reaction multiple times. |
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| Chemical derivatives: Derivatives use additional reagents and generate waste, so one should avoid using blocking or protecting groups or any temporary modifications. |
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| Maximize atom economy: Syntheses should be designed, so that the final product contains the maximum proportion of the starting materials. |
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| Safer solvents and reaction conditions: Solvents, separation agents, or other auxiliary chemicals should be avoided. If necessary, use innocuous chemicals. In case of solvents, try water or eco friendly solvents. |
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| Increase energy efficiency: Try to run chemical reactions at room temperature and pressure, to save energy. |
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| Chemicals and products should degrade after use: Design chemical products that break down into harmless, environmentally friendly substances after use. |
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| Analyze in real time to prevent pollution: Methodologies for real-time monitoring and control, must be developed to eliminate or at least minimize by-products. |
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| Minimize the potential for accidents: Chemicals and their solid, liquid or gas forms must be designed, minimising the potential for chemical accidents including explosions, fires, and releases to the environment. |